Shinshu University · University Hospital

Research keywordstherapeutic drug monitoring・perampanel pharmacokinetics・warfarin antibiotic interaction・tramadol enantiomer analysis・tolvaptan enantiomer analysis・breast milk drug transfer・tacrolimus pharmacogenetics・itraconazole metabolites

Research fields医療薬学・薬理学

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• Development and Validation of Linear Regression Models to Predict Plasma-Free Perampanel Concentrations Using Routine Clinical Data2026
• Comparison of Pharmacokinetics of Mycophenolic Acid and Its Glucuronide Between Patients With Lupus Nephritis and With Kidney Transplantation
• ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect renal function in patients with rheumatoid arthritis
• Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients

• オピオイド投与患者におけるプロクロルペラジンの体内動態と薬効・副作用との関係解明
• がん患者における病期に基づくオピオイドの鎮痛効果および有害作用の変動予測法の構築
• がん性疼痛緩和に用いる鎮痛薬の個人差要因に基づく至適薬物療法の構築
• がん病態時における末梢性μオピオイド受容体拮抗薬による臨床効果の個人差要因の解明

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