Shonan University of Medical Sciences · Faculty of Pharmacy · 助教

Research keywordsVitamin D Receptor・Nuclear Receptor Structural Biology・Small-Angle X-Ray Scattering・Molecular Dynamics Simulations・Hydrogen-Deuterium Exchange Mass Spectrometry・Covalent Modifiers・Oxo-Fatty Acids

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• Covalent Modifier Discovery Using Hydrogen/Deuterium Exchange–Mass Spectrometry
• 17-OxoDHA Is a PPARα/γ Dual Covalent Modifier and Agonist.
• Molecular interactions between piperine and peroxisome proliferator-activated receptor gamma ligand-binding domain revealed using co-crystallization studies.
• Helix12-Stabilization Antagonist of Vitamin D Receptor.

• 制御性T細胞分化調節活性を有するプレニルフラボノイドの精密構造解析と構造活性相関
• ピペリンとその異性体によるPPARγ制御に基づいた次世代糖尿病・肥満治療薬の創出研究

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