Showa Pharmaceutical University · Laboratory of Physical Chemistry of Medicines

Research keywordstargeted radionuclide therapy・multivalent RGD peptides・integrin alpha v beta 3・positron emission tomography probes・bradykinin B1 receptor imaging・photoacoustic tumor imaging・oxidized low-density lipoprotein imaging・prostate-specific membrane antigen

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• Preliminary in vitro biological evaluation of a strategy for passive intracellular glutathione-derived glyoxalase I inhibitor delivery: A novel approach. Satoru Onoe, Tomohisa Suzuki, Ayami Hirano, Keisuke Sasano, Kano Takadou, Wataru Aoyama, Shiori Oba, Manami Tsubaki, Yuki Mizuno, Miho Shukuri, Hi2025
• Design of a tetravalent RGD peptide capable of simultaneous binding with multiple integrin α v β 3 for targeted radionuclide therapy Yuki Mizuno, Thanakrit Suebboonprathueng, Satoru Onoe, Hiromichi Akizawa, Ken-Ichi Nishijima, Kazuhiro Takahashi, Yuji Kuge J. Med. Chem. 68 6518-6533 20252025
• Assessment of radiolabelled derivatives of R954 for detection of bradykinin B1 receptor in cancer cells: Studies on glioblastoma xenografts in mice. Miho Shukuri, Satoru Onoe, Tsubasa Karube, Risa Mokudai, Hayate Wakui, Haruka Asano, Shin Murai, Hiromichi Akizawa. Pharmaceuticals (Basel) 17(7) 902 22024
• Ex vivo imaging and analysis of ROS generation correlated with microglial activation in rat model with acute neuroinflammation induced by intrastriatal injection of LPS. Miho Shukuri, Miyu Uchino, Takafumi Sakamaki, Satoru Onoe, Rie Hosoi, Kenichiro Todoroki, Yasushi Arano, Toshihiro Sakai, Hiromich2021

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