Showa Pharmaceutical University · Laboratory of Clinical Pharmacy · 助教

Research keywords研究分野: 薬物動態学 急性薬物中毒・Pharmacokinetics・Pharmacology・Drug・Physiologically・based・pharmacokinetic・modelling

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• Research Letter Virtual internal exposures of lansoprazole administered to cytochrome P450 2C19 poor metabolizers estimated by simplified physiologically based pharmacokinetic modeling Makiko Shimizu, Koichiro Adachi, Yukia Shimura, Katsuhiro Ohyama, Yoichi Tanaka, Yoshiro Saito, Hiroshi Yamazaki. T2026
• Reported Liver Toxicity of Food Chemicals in Rats Extrapolated to Humans Using Virtual Human-to-Rat Hepatic Concentration Ratios Generated by Pharmacokinetic Modeling with Machine Learning-derived Parameters. Koichiro Adachi, Manato Hosoi, Yukia Shimura, Makiko Shimizu, Hiroshi Yamazaki. The Journal2025
• Virtual hepatic and plasma exposures of voriconazole administered to cytochrome P450 2C19 poor metabolizers predicted by simplified and full pharmacokinetic modeling systems: possible causal factor for hepatic disorders seen in a Japanese database. Koichiro Adachi, Katsuhiro Ohyama, Yukia Shimura, Y2025
• Modeled Hepatic/Plasma Exposures of Omeprazole Prescribed Alone in Cytochrome P450 2C19 Poor Metabolizers Are Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database. Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Norie Murayama, Makiko Shimizu, Yoshiro Saito, Hirosh2024

• 「急性薬物中毒症例への消化管除染適用時間可視化のための生理学的薬物動態モデルの適応」 日本学術振興会 科学研究費助成事業 若手研究 2023年4月 - 2026年3月（23K14393）2026
• 「アシクロビル脳症におけるアシクロビル代謝産物の毒性と診断補助指標の妥当性評価」 日本学術振興会 科学研究費助成事業 若手研究 2026年4月 - 2029年3月（26K18506）
• 急性薬物中毒症例への消化管除染適用時間可視化のための生理学的薬物動態モデルの適応
• アシクロビル脳症におけるアシクロビル代謝産物の毒性と診断補助指標の妥当性評価

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