Showa Pharmaceutical University · Laboratory of Pharmaceutics · 薬学部 教授

Research keywordspharmacokinetics・oral drug absorption・gastrointestinal physiology・PBPK modeling・drug permeability・drug interactions

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• Quantitative analysis of the effect of controlled-release formulation on nonlinear gastrointestinal absorption of CYP3A4 substrate simvastatin using a physiologically based pharmacokinetic absorption model2026
• Quantitative Analysis of the Effect of Gastrointestinal Water Dynamics on Oral Drug Absorption using a Physiologically Based Integrated Liquid and Intestinal Absorption Drug (ILIAD) Pharmacokinetic Model2026
• Differential effects of osmotic fluid dynamics on intestinal drug absorption between juvenile and adult rats: potential impact on drug interaction with hyperosmotic beverages2026
• Establishment of endogenous canine MUC1 knock-out MDCKII cells using CRISPR-Cas9 and evaluation of drug permeation2025

• 量子ドットを用いた透明化消化管イメージング解析に基づく薬物吸収動態予測法の確立2024
• 尿酸結合タンパク質CD38を介した尿酸による炎症応答調節2023
• 量子ドットによる透明化組織・細胞イメージング技術を活用した中分子ペプチド医薬の経口吸収性評価法の確立2023
• セロトニンによる体液調節機構解析を基盤にした薬物性消化器毒性評価法の確立2021

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