Showa Pharmaceutical University · Laboratory of Medicinal Chemistry

Research keywords研究分野: アミド結合またはその類縁体の合成、反応、立体化学・フッ素・アミド

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• Conformational preference of N-difluoromethylated amides: contributions of hydrogen-bonding, steric, and stereoelectronic effects Ryu Yamasaki, Ami Tashiro, Chisaki Sato, Ai Ito, and Iwao Okamoto Org. Chem. Front. 12(17) 4834–4841 20252025
• Synthesis and Conformational Analysis of N-Azulenyl-N-methyl Amides: Influence of Coplanarity on Amide Conformational Preference Ai Ito, Mari Arakawa, Masayuki Yunoki, Mayuko Tomita, Ayako Ishii, Ryu Yamasaki, and Iwao Okamoto ACS Omega 10(12) 12590–12602 20252025
• Synthesis and conformational analysis of N-aromatic acetamides bearing thiophene: effect of intramolecular chalcogen-chalcogen interaction on amide conformational stability. Ai Ito, Marino Asato, Yuki Asami, Kazuo Fukuda, Ryu Yamasaki, Iwao Okamoto J. Org. Chem. 88 (11) 7075–7087 20232023
• Structure and Additive-free Transamidation of Planar N-Cyano Amides. Ryu Yamasaki, Yuko Okada, Hiromi Iizumi, Ai Ito, Kazuo Fukuda, Iwao Okamoto J. Org. Chem. 88 (9) 5704–5712 20232023

• フルオロカーボンによるアミド窒素修飾の化学
• 機能化を指向したSPMを用いたロタキサン類化合物合成法の開発

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