St. Marianna University School of Medicine · Faculty of Medicine / Graduate School of Medicine · 教授

Research keywordsDNA修復・ユビキチン・BRCA1・乳癌・腫瘍学・Breast・cancer・Oncology

Research fields乳腺外科・Molecular biology・Cell biology

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• Ribosomal S6 kinase (RSK) plays a critical role in DNA damage response via the phosphorylation of histone lysine demethylase KDM4B.
• HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.
• Putative tumor suppressor EDD interacts with and up-regulates APC
• Alterations in CD45 glycosylation pattern accompanying different cell proliferation states

• ユビキチンリガーゼBRCAIの機能解析と標的基質の解明
• BRCA1ユビキチンリガーゼによるDNA損傷応答
• ユビキチンリガーゼBRCA1-BARD1によるDNA修復および転写の制御
• HERC2によるS期およびG2/M期チェックポイント制御機構の解析

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