St. Marianna University School of Medicine · School of Medicine · 教授

Research keywordsKMT2A・MLL・Research・急性リンパ性白血病・混合性白血病

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• Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study.
• Disappearance of both the BCR/ABL1 fusion gene and the JAK2V617F mutation with dasatinib therapy in a patient with imatinib-resistant chronic myelogenous leukemia.
• Outcomes of Patients with Early Hyperbilirubinemia after Allogeneic Hematopoietic Stem Cell Transplantation.
• Activated K-Ras protein accelerates human MLL/AF4-induced leukemo-lymphomogenicity in a transgenic mouse model.

• MLL/AF4 陽性ALL のS100A6 抑制による新規治療開発
• KMT2A/AFF1陽性急性リンパ性白血病のS100A6阻害併用造血幹細胞移植法の確立
• S100A6阻害をターゲットとした切除不能膵癌の新規免疫治療の開発
• 新規RCSD1-ABL1 遺伝子癌化能と分子標的薬開発

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