Takasaki University of Health and Welfare · Faculty of Pharmaceutical Sciences · 准教授

Research keywordsdrug metabolism・androgen receptor・hepatocyte toxicity・constitutive androstane receptor・nafld・oxidative stress・cyp1a2 regulation

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• Interaction Between PHF8 and a Segment of KDM2A, Which Is Controlled by the Phosphorylation Status at a Specific Serine in an Intrinsically Disordered Region of KDM2A, Regulates rRNA Transcription and Cell Proliferation in a Breast Cancer Cell Line
• p38-Mediated phosphorylation of Eps15 endocytic adaptor protein
• Hepatocyte nuclear factor 4α regulates expression of the mouse female-specific Cyp3a41 gene in the liver.
• Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population

• リン酸化アンドロゲン受容体のがん抑制作用の分子解明による前立腺がん獲得耐性克服
• 成長ホルモン及びHNF3βまたは4αによる性特異的シトクロムP450発現調節
• 個別化医療に繋がる成長ホルモンによるCYP1A2の性特異的発現調節の分子的解明
• チロシンキナーゼ型受容体ErbBフィードバック阻害機構の解明によるがん分子標的薬耐性の克服

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