Teikyo University · Faculty of Pharmaceutical Sciences · 准教授

Research keywordsParkinson disease・LRRK2 signaling・PINK1 biology・Rab phosphorylation・autonomic pathology

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• BORCS6 is involved in the enlargement of lung lamellar bodies in Lrrk2 knockout mice2021
• Lack of Correlation between the Kinase Activity of LRRK2 Harboring Kinase-Modifying Mutations and Its Phosphorylation at Ser910, 935, and Ser955
• Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1
• Site-Specific Aspartic Acid D-Isomerization in Tau R2 and R3 Peptide Seeds Attenuates Seed-Induced Fibril Formation of Full-Length Tau

• 家族性パーキンソン病病因遺伝子産物LRRK2の生理・病理学的基質の探索
• 家族性パーキンソン病責任遺伝子産物LRRK2の機能解析
• 病原性タウの脳内伝播を担うエクソソームの輸送先決定機構の解明と治療応用
• シナプスを標的とするアルツハイマー病の病態解明と治療

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