Teikyo University · Faculty of Science and Engineering · 教授

Research keywords自閉スペクトラム症 SHANK3・NMDA・受容体・阻害剤探索・開発

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• Time-dependent enhancement of hippocampus-dependent memory after treatment with memantine: Implications for enhanced hippocampal adult neurogenesis.
• A single amino acid residue determines the Ca2+ permeability of AMPA-selective glutamate receptor channels.
• Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.
• Evaluation of agonist selectivity for the NMDA receptor ion channel in bilayer lipid membranes based on integrated single-channel currents

• シナプス機能分子の動態解析に関する研究
• シナプス機能分子Shank3に起因した広汎性発達障害の神経病態の解明
• ニューロン・ミクログリア相関による機能的神経回路形成の分子基盤の解明
• 自閉症病態モデルマウスにおけるシナプス病態の分子基盤の解明

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