Teikyo University · Faculty of Pharmaceutical Sciences · 教授

Research keywordsオキシコドン・P糖タンパク質・RNA干渉・アミトリプチリン・オピオイド・鎮痛補助薬・鎮痛耐性・鎮痛作用・遺伝子解析・血液脳関門

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• Naltrexone Transport by a Proton-Coupled Organic Cation Antiporter in hCMEC/D3 Cells, an in Vitro Human Blood-Brain Barrier Model.
• Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model.
• Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone
• In vivo measurement by [H-3]tamsulosin of alpha(1) adrenoceptors in rat tissues in relation to the pharmacokinetics

• 麻薬性鎮痛薬の薬効を制御する血液脳関門輸送機構の解明
• 新規ヒト血液脳関門細胞株を用いた中枢治療薬の脳移行性予測
• 薬剤性認知症回避を目指した抗コリン薬の新規リスク指標開発
• 有機カチオン感受性トランスポーターを介した麻薬性鎮痛薬の血液脳関門輸送

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