Institute of Science Tokyo · Graduate School of Medical and Dental Sciences

Research keywordsintestinal organoids・Wnt signaling activation・patient-derived organoids・regenerative cell therapy・induced pluripotent stem cells・self-organizing human intestine

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• Hady Yuki Sugihara, Sayaka Nagata, Sho Kawasaki, Junichi Takahashi, Yui Hiraguri, Masayoshi Fukuda, Kohei Suzuki, Tatsuro Murano, Satoru Fujii, Toshimitsu Fujii, Hiromichi Shimizu, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto , Tomohiro Mizutani. Peptide-based Wnt signal activation enables scalable production of clinical-grade patient-derived intestinal organoids for regenerative cell therapy Stem Cell Research & Therapy . 2026.03; ( PubMed , DOI )2026
• Junichi Takahashi, Hady Yuki Sugihara, Shu Kato, Sho Kawasaki, Sayaka Nagata, Ryuichi Okamoto, Tomohiro Mizutani. Controlled aggregative assembly to form self-organizing macroscopic human intestine from induced pluripotent stem cells. Cell Rep Methods. 2024.12; 4 (12): 100930. ( PubMed , DOI )2024
• Kazunori Sugimura, Osamu Sasaki, Masahiro Shinoda, Sho Kawasaki, Masaharu Shinkai. Catamenial pneumothorax: a cause of monthly breathlessness. Lancet. 2019.09; 394 (10202): 952. ( PubMed , DOI )2019

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