Institute of Science Tokyo · Institute for Advanced Studies

Research keywordsprotein structure prediction・biosynthetic enzymes・enzyme catalytic mechanisms・lincosamide biosynthesis・antiviral peptides・protein-ligand complexes・generative protein design

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• Ryo Akiba, Yoshitaka Moriwaki, Ryuichiro Ishitani, Naruki Yoshikawa. Multi-objective optimization for designing structurally similar proteins with dissimilar sequences Science and Technology of Advanced Materials: Methods. 2026.01; 2611575. ( DOI )2026
• Nayuta Nagano, Koichi Kiuchi, Atsushi Minato, Shusuke Sato, Yoshitaka Moriwaki, Rolf Müller, Tadashi Eguchi, Fumitaka Kudo. 4″-Methyl-S-Adenosyl-L-Methionines Are Substrates for 4-Methylazetidinecarboxylic Acid Synthases ACS Chemical Biology. 2026.01; 21 (2): 224-229. ( DOI )2026
• Tomohiro Noguchi, Fan Zhao, Yoshitaka Moriwaki, Hideaki Yamamoto, Kei Kudo, Ryuhei Nagata, Takeo Tomita, Tohru Terada, Kentaro Shimizu, Makoto Nishiyama, Tomohisa Kuzuyama. Biosynthesis of the tetrahydroxynaphthalene-derived meroterpenoid furaquinocin via reductive deamination and intramolecular hydroalkoxylation of an alkene Chemical Science. 2025.03; 16 7912-7920. ( DOI )2025
• Aiko Watanabe, Shizuka Ogiwara, Mirei Saito, Masaki Mishima, Masahiro Yamashina, Ryuichiro Ishitani, Yutaka Ito, Keiji Tanaka, Fumika Koyano, Koji Yamano, Hidetaka Kosako, Yoshitaka Moriwaki, Noriyuki Matsuda. The reaction mechanism for glycolysis side product degradation by Parkinson’s disease–linked DJ-1 Journal of Cell Biology. 2025.06; 224 (8): e202411078. ( DOI )2025

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