Institute of Science Tokyo · Graduate School of Medical and Dental Sciences

Research keywordsintestinal organoids・regenerative cell therapy・induced pluripotent stem cells・Wnt signaling activation・rotating bioreactors・inflammatory bowel disease

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• Hady Yuki Sugihara, Sayaka Nagata, Sho Kawasaki, Junichi Takahashi, Yui Hiraguri, Masayoshi Fukuda, Kohei Suzuki, Tatsuro Murano, Satoru Fujii, Toshimitsu Fujii, Hiromichi Shimizu, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto, Tomohiro Mizutani. Peptide-based Wnt signal activation enables scalable production of clinical-grade patient-derived intestinal organoids for regenerative cell therapy. Stem Cell Res Ther. 2026.03; ( PubMed , DOI )2026
• Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani. Intestinal organoids: The path towards clinical application. Eur J Cell Biol. 2025.03; 104 (1): 151474. ( PubMed , DOI )2025
• Junichi Takahashi, Hady Yuki Sugihara, Shu Kato, Sho Kawasaki, Sayaka Nagata, Ryuichi Okamoto, Tomohiro Mizutani. Controlled aggregative assembly to form self-organizing macroscopic human intestine from induced pluripotent stem cells. Cell Rep Methods. 2024.12; 4 (12): 100930. ( PubMed , DOI )2024
• Junichi Takahashi, Hady Yuki Sugihara, Shu Kato, Sayaka Nagata, Ryuichi Okamoto, Tomohiro Mizutani. Protocol to generate large human intestinal organoids using a rotating bioreactor. STAR Protocols. 2023.06; 4 (3): 102374. ( PubMed , DOI )2023

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