Institute of Science Tokyo · International Research Institute for Medical-Engineering Collaboration

Research keywordsmRNA delivery・polyplex micelles・nucleic acid therapeutics・RNase resistance・DNA nanocarriers・systemic delivery

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• Martin JD, Toh K, Martin MR, Chen P, Wang C, Igarashi K, Mpekris F, Stylianopoulos T, Stuber MD, Kataoka K, Cabral H. Bone marrow vessels are hyperpermeable to macromolecules and nanoscale medicine in a size-dependent manner. Journal of controlled release : official journal of the Controlled Release Society. 2025.06; 382 113669. ( PubMed , DOI )2025
• Chaya, H; Naito, M; Toh, K; Yamada, N; Taniwaki, K; Kinoshita, Y; Fukushima, S; Minegishi, K; Aoki, Y; Nagata, T; Yokota, T; Kataoka, K; Miyata, K. Enhanced Accumulation of Heteroduplex Oligonucleotides in Dystrophin-Deficient Skeletal Muscles by Single Oligonucleotide-Loaded Unit Polyion Complexes ACS OMEGA. 2025.08; 10 (31): 34363-34371. ( PubMed , DOI )2025
• Dirisala A, Uchida S, Toh K, Li J, Liu X, Wen P, Fukushima S, Kataoka K. Structural stability and RNase resistance of mRNA Polyplex micelles for systemic delivery. Journal of controlled release : official journal of the Controlled Release Society. 2025.08; 384 113935. ( PubMed , DOI )2025
• Suzuki, M; Mochida, Y; Hori, M; Hayashi, A; Toh, K; Tockary, TA; Liu, XY; Marx, V; Yokoo, H; Miyata, K; Oba, M; Uchida, S. Poly(ethylene Glycol) (PEG)-OligoRNA Hybridization to mRNA Enables Fine-Tuned Polyplex PEGylation for Spleen-Targeted mRNA Delivery SMALL SCIENCE. 2024.04; 4 (4): 2300258. ( PubMed , DOI )2024

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