Institute of Science Tokyo · Graduate School of Medical and Dental Sciences

Research keywordshepatocellular carcinoma・biliary tract cancer・epigenetic regulation・lipotoxicity・histone citrullination・colorectal cancer・immune checkpoint blockade・tumor metabolism

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• Umemura K, Akiyama Y, Shimada S, Hatano M, Kono A, Yasukawa K, Kamachi A, Igarashi Y, Tsukihara S, Tanji Y, Morimoto K, Nara A, Yamane M, Akahoshi K, Ono H, Shimizu A, Soejima Y, Tanabe M, Ban D,Tanaka S. PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer. Molecular Cancer Research. 2025.08; 23 (10): 844-858. ( PubMed , DOI )2025
• Atsushi Nara, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Yusuke Chino, Suguru Miyazawa, Hanako Tamura, Daisuke Asano, Yoshiya Ishikawa, Hiroki Ueda, Shuichi Watanabe, Eriko Katsuta, Keiichi Akahoshi, Kenichi Ohashi, Minoru Tanabe, Daisuke Ban, Shinji Tanaka. Targeting SPP1-CD44-Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis. Cancer Sci. 2025.12; Online ahead of print. ( PubMed , DOI )2025
• Koya Yasukawa, Shu Shimada, Yoshimitsu Akiyama, Tomohiko Taniai, Yosuke Igarashi, Shu Tsukihara, Yoshiaki Tanji, Kentaro Umemura, Atsushi Kamachi, Atsushi Nara, Masahiro Yamane, Keiichi Akahoshi, Akira Shimizu, Yuji Soejima, Minoru Tanabe, Shinji Tanaka. ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma. Cell Rep Med. 2025.04; 6 (4): 102038. ( PubMed , DOI )2025
• Tsukihara S, Akiyama Y, Shimada S, Hatano M, Igarashi Y, Taniai T, Tanji Y, Kodera K, Yasukawa K, Umeura K, Kamachi A, Nara A, Okuno K, Tokunaga M, Katoh H, Ishikawa S, Ikegami T, Kinugasa Y, Eto K, Tanaka S. Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer. Oncogene. 2025.03; 44 (11): 724-738. ( PubMed , DOI )2025

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