Institute of Science Tokyo · Graduate School of Medical and Dental Sciences

Research keywordsbrown adipose tissue thermogenesis・PGC-1alpha・phospholipid synthesis・aldosterone-producing adenoma heterogeneity・circulating microRNAs・prediabetes detection by electrocardiography・primary aldosteronism・lipodystrophy endocrinology

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• Masato Horino, Kenji Ikeda, Rei Okazaki, Yujiro Nakano, Ryo Kaneda, Ryoko Ishii, Jun Aoki, Kazunari Hara, Akira Takeuchi, Yoshihiro Niitsu, Kuniyuki Taguchi, Kuniyuki Kano, Masanori Murakami, Kazutaka Tsujimoto, Chikara Komiya, Tetsuya Yamada. Car4-positive adipocyte progenitor cells adapt to the aging environment and work as protection against ROS via glutathione metabolism. Sci Rep. 2025.08; 15 (1): 31922. ( PubMed , DOI )2025
• Akira Takeuchi, Kazutaka Tsujimoto, Jun Aoki, Kenji Ikeda, Nozomu Kono, Kuniyuki Kano, Yoshihiro Niitsu, Masato Horino, Kazunari Hara, Rei Okazaki, Ryo Kaneda, Masanori Murakami, Kumiko Shiba, Chikara Komiya, Junken Aoki, Tetsuya Yamada. Sex difference in BAT thermogenesis depends on PGC-1α-mediated phospholipid synthesis in mice. Nat Commun. 2025.07; 16 (1): 6072. ( PubMed , DOI )2025
• Daisuke Koga, Ryo Kaneda, Chikara Komiya, Satoshi Ohno, Akira Takeuchi, Kazunari Hara, Masato Horino, Jun Aoki, Rei Okazaki, Ryoko Ishii, Masanori Murakami, Kazutaka Tsujimoto, Kenji Ikeda, Hideki Katagiri, Hideyuki Shimizu, Tetsuya Yamada. Artificial intelligence identifies individuals with prediabetes using single-lead electrocardiograms. Cardiovasc Diabetol. 2025.11; 24 (1): 415. ( PubMed , DOI )2025
• Hara K, Murakami M, Shiba K, Tsujimoto K, Komiya C, Ikeda K, Yamamoto K, Taguchi T, Akashi T, Yoshida S, Ohashi K, Fujii Y, Yamada T.. Unexpected Remission of Bilateral Hyperaldosteronism After Unilateral Cortisol-Producing Adenoma Resection: A Report of Two Cases. Case Rep Endocrinol.. 2025.06; 9941688 ( PubMed )2025

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