Institute of Science Tokyo · Institute for Advanced Studies · 教授

Research keywordsパーキンソン病・ミトコンドリア・Omi・包括脳ネットワーク・発癌・神経変性疾患・細胞死・統合脳・病態脳・膜透過性亢進・mnd2

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• Tatsuya Hasegawa, Saori Noguchi, Masaya Nakashima, Masashi Miyai, Makiko Goto, Yuko Matsumoto, Satoru Torii, Shinya Honda, Shigeomi Shimizu. Alternative autophagy dampens UVB-induced NLRP3 inflammasome activation in human keratinocytes. J Biol Chem. 2024.03; 107173. ( PubMed , DOI )2024
• Di Wang, Shinya Honda, Min Kyoung Shin, Kei Watase, Hidehiro Mizusawa, Kinya Ishikawa, Shigeomi Shimizu. Subcellular localization and ER-mediated cytotoxic function of α1A and α1ACT in spinocerebellar ataxia type 6. Biochem Biophys Res Commun. 2024.02; 695 149481. ( PubMed , DOI )2024
• Tomoyo Yoshida, Tadashi Yokoi, Taku Tanaka, Emiko Matsuzaka, Yuki Saida, Sachiko Nishina, Shuji Takada, Shigeomi Shimizu, Noriyuki Azuma. Modeling of Retina and Optic Nerve Ischemia-Reperfusion Injury through Hypoxia-Reoxygenation in Human Induced Pluripotent Stem Cell-Derived Retinal Ganglion Cells. Cells. 2024.01; 13 (2): ( PubMed , DOI )2024
• Tomoki Yanagi, Hiroaki Kikuchi, Koichiro Susa, Naohiro Takahashi, Hiroki Bamba, Takefumi Suzuki, Yuta Nakano, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Shintaro Mandai, Takayasu Mori, Koh Takeuchi, Shinya Honda, Satoru Torii, Shigeomi Shimizu, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara. Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression. Genes Cells. 2023.01; 28 (1): 5-14. ( PubMed , DOI )2023

• アポトーシスにおけるミトコンドリア膜透過性亢進因子の同定とその分子機構の解明
• Analysis of Molecular Mechanism of Apoptosis
• 肝虚血障害機構の遺伝学的解明と細胞死抑制遺伝子bc1−2導入による保護
• 新規アポトーシス遺伝子の作用機構と臨床応用に関する研究

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