Institute of Science Tokyo · Graduate School of Medical and Dental Sciences

Research keywordstoxicologic pathology・aristolochic acid nephrotoxicity・thallium toxicity・arsenic toxicology・autophagy dysfunction・epithelial mesenchymal transition・mitochondrial injury

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• Komatsu M, Funakoshi T, Aki T, Unuma K. Aristolochic Acid-Induced DNA Adduct Formation Triggers Acute DNA Damage Response in Rat Kidney Proximal Tubular Cells. Toxicology letters. 2025.02; ( PubMed , DOI )2025
• Miu Kajihara, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma. Slow-releasing hydrogen sulfide donor GYY4137 induces epithelial-mesenchymal transition in A549 human lung adenocarcinoma cells. J Toxicol Sci. 2025; 50 (8): 425-430. ( PubMed , DOI , 医中誌 )2025
• Kana Unuma, Shuheng Wen, Sho Sugahara, Shutaro Nagano, Toshihiko Aki, Tadayuki Ogawa, Shino Takeda-Homma, Masakazu Oikawa, Akihiro Tojo. Thallium reabsorption via NKCC2 causes severe acute kidney injury with outer medulla-specific calcium crystal casts in rats. Arch Toxicol. 2024.10; ( PubMed , DOI )2024
• Sho Sugahara, Kana Unuma, Shuheng Wen, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Dissociation of mitochondrial and ribosomal biogenesis during thallium administration in rat kidney. PLoS One. 2024; 19 (12): e0311884. ( PubMed , DOI )2024

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