Institute of Science Tokyo · Graduate School of Medical and Dental Sciences

Research keywordstendon development・periodontal ligament・cartilage homeostasis・Sox9 regulation・Mkx・single-cell transcriptomics・mechanotransduction・orthodontic tooth movement・PIEZO1・Tol2 gene editing

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• Masayasu Sega, Yutaro Uchida, Tomoki Chiba, Takahide Matsushima, Kohei Kita, Naoyuki Miyasaka, Hiroshi Asahara. Stage- and cluster-specific regulation of chondrogenic gene programs by Sox9 in mouse embryonic limb buds. iScience. 2026.03; 29 (3): 115074. ( PubMed , DOI )2026
• Lin Liu, Tomoki Chiba, Takahide Matsushima, Maiko Inotsume, Tomomi Kato, Yuichi Hiraoka, Hiroshi Asahara. Gene dosage-dependent roles of Mkx in postnatal tendon development and maintenance revealed by conditional deletion. Dev Biol. 2025.10; 526 15-25. ( PubMed , DOI )2025
• Suzu Chida, Tomoki Chiba, Yutaro Uchida, Takahide Matsushima, Ryota Kurimoto, Takayuki Miyazaki, Lisa Yagasaki, Satoshi Nakamura, Emiko Mihara, Junichi Takagi, Keiji Moriyama, Hiroshi Asahara. Impact of mechanotransduction on gene expression changes in periodontal ligament during orthodontic tooth movement. J Bone Miner Metab. 2025.02; ( PubMed , DOI )2025
• Lisa Yagasaki, Tomoki Chiba, Ryota Kurimoto, Mitsuyo Nakajima, Takanori Iwata, Hiroshi Asahara. in periodontal ligament on the metabolism of alveolar bone and cementum. Regen Ther. 2024.03; 25 186-193. ( PubMed , DOI )2024

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