Meijo University · Faculty of Pharmaceutical Sciences · 薬学部 助教

Research keywordsUnfolded Protein Response・Tissue-specific ER stress response・ER stress

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• Development of a Rapidin vivoAssay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response Using Medaka Fish
• Tango1L but not Tango1S, Tali and cTAGE5 is required for export of type II collagen in medaka fish.
• Activation of XBP1 but not ATF6α rescues heart failure induced by persistent ER stress in medaka fish
• Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice

• 組織特異的小胞体ストレス応答の分子機構に基づくヒト慢性疾患治療戦略の創出を目指した研究
• メダカを用いた脂肪肝疾患の新しい発症機構の解明
• メダカを用いて挑む小胞体ストレスに起因する細胞死メカニズムの解明
• メダカを用いた小胞体ストレスに起因するアポトーシス分子機構の解析

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