Tohoku University · Faculty of Medicine / Graduate School of Medical Sciences

Research keywordserythropoiesis・GATA1 gene regulation・GATA2-EVI1 leukemogenesis・KEAP1-NRF2 signaling・sickle cell disease・fetal hemoglobin regulation・chemical carcinogenesis・Down syndrome transient abnormal myelopoiesis

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• The Gata1 5 ' region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCsJun Takai, Takashi Moriguchi, Mikiko Suzuki, Lei Yu, Kinuko Ohneda, Masayuki Yamamoto
• Differential contribution of the Gata1 gene hematopoietic enhancer to erythroid differentiation.Suzuki Mikiko, Moriguchi Takashi, Ohneda Kinuko, Yamamoto Masayuki
• Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors.Makiko Hayashi, Ayumi Kuga, Mikiko Suzuki, Harit Panda, Hiroshi Kitamura, Hozumi Motohashi, Masayuki Yamamoto
• Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndromeTsutomu Toki, Rika Kanezaki, Eri Kobayashi, Hiroshi Kaneko, Mikiko Suzuki, RuNan Wang, Kiminori Terui, Hirokazu Kanegane, Miho Maeda, Mikiya Endo, Tatsuki Mizuochi, Souichi Adachi, Yasuhide Hayashi, Masayuki Yamamoto, Ritsuko Shimizu, Etsuro Ito

• EVI1-GATA2バランスによる3q白血病悪性化機構の解析鈴木 未来子
• がん微小環境構成要素としての前がん細胞の役割山本 雅之, 鈴木 未来子
• 成人の定常状態造血を維持するエリスロポエチン産生制御機構と病態との関係峯岸 直子, 鈴木 未来子, 平野 育生, 鈴木 教郎, 相馬 友和, 山嵜 瞬
• β型グロビン遺伝子のエピジェネティック制御におけるDNAメチル基転移酵素1の役割田邉 修, 鈴木 未来子, 横澤 潤二, 西川 慧

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