Tohoku University · Graduate School of Biomedical Engineering

Research keywordskidney disease・renal metabolomics・ADPKD・acute kidney injury・renal progenitor cells・uremic solutes・renal tubular oxidative stress

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• HPRT-related hyperuricemia with a novel p.V35M mutation in HPRT1 presenting familial juvenile gout.Eikan Mishima, Takayasu Mori, Yoko Nakajima, Takafumi Toyohara, Koichi Kikuchi, Yoshitsugu Oikawa, Tetsuro Matsuhashi, Yasuhiro Maeda, Takehiro Suzuki, Masataka Kudo, Sadayoshi Ito, Eisei Sohara, Shinichi Uchida, Takaaki Abe
• CE-MS-Based Identification of Uremic Solutes Specific to Hemodialysis PatientsAkiyama Y, Kikuchi K, Toyohara T, Mishima E, Suzuki C, Suzuki T, Nakayama M, Tomioka Y, Soga T, Abe T
• Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.Takafumi Toyohara, Filip Roudnicky, Mary H C Florido, Toshiaki Nakano, Haojie Yu, Shunsuke Katsuki, Minjin Lee, Torsten Meissner, Max Friesen, Lance S Davidow, Leon Ptaszek, Takaaki Abe, Lee L Rubin, Alexandre C Pereira, Masanori Aikawa, Chad A Cowan
• GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis.Haojie Yu, Antoine Rimbert, Alice E Palmer, Takafumi Toyohara, Yulei Xia, Fang Xia, Leonardo M R Ferreira, Zhifen Chen, Tao Chen, Natalia Loaiza, Nathaniel Brooks Horwitz, Michael C Kacergis, Liping Zhao, Alexander A Soukas, Jan Albert Kuivenhoven, Sekar Kathiresan, Chad A Cowan

• リン脂質を調節する新規動脈硬化抑制系路を介した動脈防御戦略の国際共同研究2022 · 2022年4月 ～ 2025年3月
• 内皮-平滑筋相互作用におけるRNF213の役割ともやもや病発症機序解明新妻 邦泰, Rashad Sherif, 菅野 新一郎, 森戸 大介, 豊原 敬文, 阿部 高明, 坂田 洋之
• 細胞内脂質に着目した新たな糖尿病性腎症治療法の開発豊原 敬文
• 糖尿病性腎症の治療を目指したヒト多能性幹細胞から糸球体内皮細胞への誘導法の開発豊原 敬文

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