Tohoku University · Institute of Development, Aging and Cancer

Research keywordsmitochondrial diseases・mitochondrial DNA・mitochondrial RNA processing・mtDNA replication・mitochondrial transcription factor A・RNA modification・epigenetic features of mtDNA

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• TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication.Teppei Inatomi, Shigeru Matsuda, Takashi Ishiuchi, Yura Do, Masunari Nakayama, Shusaku Abe, Kazutoshi Kasho, Sjoerd Wanrooij, Kazuto Nakada, Kenji Ichiyanagi, Hiroyuki Sasaki, Takehiro Yasukawa, Dongchon Kang
• The accessory subunit of human DNA polymerase γ is required for mitochondrial DNA maintenance and is able to stabilize the catalytic subunit.Yura Do, Shigeru Matsuda, Teppei Inatomi, Kazuto Nakada, Takehiro Yasukawa, Dongchon Kang
• Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation.Haruna Tani, Kaori Ishikawa, Hiroaki Tamashiro, Emi Ogasawara, Takehiro Yasukawa, Shigeru Matsuda, Akinori Shimizu, Dongchon Kang, Jun-Ichi Hayashi, Fan-Yan Wei, Kazuto Nakada
• Chemogenetic activation of hepatic G12 signaling ameliorates hepatic steatosis and obesity.Kaito Arai, Yuki Ono, Natsumi Hirai, Yuki Sugiura, Keizo Kaneko, Shigeru Matsuda, Keita Iio, Keita Kajino, Tsuyoshi Saitoh, Fan-Yan Wei, Hideki Katagiri, Asuka Inoue

• 加齢に伴うミトコンドリアDNA複製の変容と新規老化制御機構の解明松田 盛
• RNAモドミクスを基軸とする新規核酸生理学の開拓魏 范研, 小川 亜希子, 松田 盛
• 新規探索ツールによるミトコンドリア内転写因子と疾患・老化の関連の解析松田 盛
• ミトコンドリアのエピゲノム修飾がもたらす加齢現象の解明松田 盛

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