Tohoku Medical and Pharmaceutical University · Graduate School of Pharmaceutical Sciences · 准教授

Research keywords薬剤耐性・細胞機能・殺菌ペプチド・好中球・がん・P-糖タンパク質・薬学

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• Antibacterial cathelicidin peptide CAP11 suppresses the anandamide production from lipopolysaccharide-stimulated mononuclear phagocytes.
• Characterization of cells resistant to the potent histone deacetylase inhibitor spiruchostatin B (SP-B) and effect of overexpressed p21(waf1/cip1) on the SP-B resistance or susceptibility, Of human leukemia cells
• Involvement of p21(waf1/cip1) expression in the cytotoxicity of the potent histone deacetylase inhibitor spiruchostatin B towards susceptible NALM-6 human B cell leukemia cells
• Effect of Sizofilan, an Immunomodulator, on Hepatic Microsomal Mixed-Function Oxidase Activities in Rats

• ゴマリグナン類の抗がん作用の機能解明
• 多剤耐性に寄与するP-糖タンパク質の発現の速さと量を規定する因子の同定
• SecinH3は新たなメカニズムでABCトランスポーターを抑制するのか
• がん細胞における新規耐性マーカーとしてのＡＲＦ―ＧＥＰ１００の検討

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