Tohoku Medical and Pharmaceutical University · Graduate School of Pharmaceutical Sciences · 教授

Research keywords毒性発現機構・環境汚染物質・脳内炎症・重金属

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• The polypeptide antibiotic polymyxin B acts as a pro-inflammatory irritant by preferentially targeting macrophages
• Overexpression of Rad23 confers resistance to methylmercury in yeast cells via inhibition of degradation of Png1
• Methylmercury causes neuronal cell death via M1-microglial activation in organotypic slices prepared from mouse cerebral cortex
• Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos

• 転写因子TCF3によるメチル水銀毒性軽減機構の解明
• Rad23を介したユビキチン化蛋白質の分解抑制によるメチル水銀毒性軽減機構の解明
• メチル水銀毒性の発現機構解明とその応用
• カドミウムが引き起こす新規機構による小胞体ストレス

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