Tohoku Medical and Pharmaceutical University · Unclassified

Research keywordsペプチド化学・創薬化学・オピオイドペプチド・リガンド設計・細胞膜透過ペプチド

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• Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.
• Endomorphin analogues with mixed μ-opioid (MOP) receptor agonism/δ-opioid (DOP) receptor antagonism and lacking β-arrestin2 recruitment activity.
• Receptor binding properties and antinociceptive effects of chimeric peptides consisting of a micro-opioid receptor agonist and an ORL1 receptor antagonist.
• Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.

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