Tohoku Medical and Pharmaceutical University · Graduate School of Pharmaceutical Sciences · 教授

Research keywordsアンジオテンシン・鎮痛・神経ペプチド・Pain・痛み・Analgesia・Neuropeptides

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• Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism
• Angiotensin-Related Peptides and Their Role in Pain Regulation
• AMPK activation improves depression-like symptoms in olfactory bulbectomized mice by regulating microglia M1/M2 polarization in the hippocampus
• Effectiveness of Angiotensin System Inhibitors Against Painful Peripheral Neuropathy in Type 2 Diabetic Old Patients: Validation by Analysis of Pharmacy Claims Data

• 新規疎水性構造を利用した分子設計による受容体制御の新たな展開
• 海馬神経細胞新生促進を目指した精神疾患予防・治療法の開発
• 脊髄内TNF-α変換酵素による細胞外領域シェディングを介した疼痛制御機構
• 慢性疼痛における脊髄アンジオテンシン系の役割の解明：新規治療法の開発を目指して

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