Tohoku Medical and Pharmaceutical University · Faculty of Medicine, Department of Medicine · 講師

Research keywords作用機序・化学予防・標的タンパク質・食品成分・がん予防・医学・歯学・薬学・保健

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• Caffeic acid suppresses cyclin D1 expression by directly binding to ribosomal protein S5 in colorectal cancer cells
• Sodium salicylate and 5-aminosalicylic acid synergistically inhibit the growth of human colon cancer cells and mouse intestinal polyp-derived cells
• Resibufogenin induces G1-phase arrest through the proteasomal degradation of cyclin D1 in human malignant tumor cells
• Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling

• ケミカルバイオロジーによる癌予防標的分子の網羅的同定と癌のテーラーメイド予防
• メトホルミンを用いたがんの化学予防実現のための分子基盤の確立
• 新たに発見された発がん要因に対する予防法の開発
• 新規に同定したメトホルミン結合タンパク質に基づく、がん予防効果の全貌解明

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