Tohoku Medical and Pharmaceutical University · Graduate School of Medicine · 准教授

Research keywords喘息・性特異的免疫応答・樹状細胞・オピオイド受容体・Th2免疫応答・気道上皮細胞・遺伝子多型

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• Dectin-2-dependent NKT cell activation and serotype-specific antibody production in mice immunized with pneumococcal polysaccharide vaccine.
• Development and evaluation of a quantitative assay detecting cytomegalovirus transcripts for preemptive therapy in allogeneic hematopoietic stem cell transplant recipients.
• Cryptococcus neoformans suppresses the activation of bone marrow-derived dendritic cells stimulated with its own DNA, but not with DNA from other fungi.
• The involvement of glucocorticoids in psychological stress-induced exacerbations of experimental allergic asthma.

• 生活環境要因に起因する気管支喘息重症化機序の解明と疾患フェノタイプ特異的治療法の確立にむけた基盤的研究
• 気管支喘息におけるオピオイド受容体遺伝子多型によるTh2免疫応答制御の基盤研究
• 包括的遺伝子型解析から導く抗TSLP抗体治療無効群における新規エンドタイプの解明
• 喘息重症化を担う肺神経内分泌細胞の制御機構におけるオピオイドシグナルバランスの役割

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