Tohoku Medical and Pharmaceutical University · Graduate School of Pharmaceutical Sciences · 教授

Research keywordsNMR・脳神経疾患・糖鎖・糖タンパク質・生物物理・構造生物学・安定同位体標識・分子認識・薬学・質量分析

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• Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy.
• Peptide recognition: Encapsulation and alpha-helical folding of a nine-residue peptide within a hydrophobic dimeric capsule of a bowl-shaped host
• Each N-glycan on human IgA and J-chain uniquely affects oligomericity and stability
• Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signalling (vol 34, pg 838, 2014)

• がん治療へむけた分子シャペロン補因子ＨＯＰの阻害剤の創出
• 脳イメージングを基軸としたタンパク質老化モデルの治療評価系の開発
• 味覚修飾タンパク質クルクリンの機能発現メカニズムの解明とその応用
• 糖鎖が関わる小胞体関連分解の構造生物学的研究

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