Tohoku Medical and Pharmaceutical University · Graduate School of Pharmaceutical Sciences · 准教授

Research keywordsmarine lectins・glycan-mediated cytotoxicity・catfish egg lectin・rhamnose-binding lectins・apoptosis induction・cancer-selective lectins

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• Binding profiles and cytokine-inducing effects of fish rhamnose-binding lectins on Burkitt's lymphoma Raji cells.
• A lectin from the mussel Mytilus galloprovincialis has a highly novel primary structure and induces glycan-mediated cytotoxicity of globotriaosylceramide-expressing lymphoma cells.
• [Catfish (Silurus asotus) lectin enhances the cytotoxic effects of doxorubicin].
• MRP1 expressed on Burkitt's lymphoma cells was depleted by catfish egg lectin through Gb3-glycosphingolipid and enhanced cytotoxic effect of drugs.

• 海洋動物レクチンを細胞内に取り込む分子機序とそれを利用した新規がん治療法の開発

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