Tohoku University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 教授

Research keywordschemistry・遺伝子医学・ヘテロ環化合物・有機合成化学・コンビナトリアル合成・Catalysis・Organic・Stereochemistry

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• Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension.Ryo Kurosawa, Kimio Satoh, Nobuhiro Kikuchi, Haruhisa Kikuchi, Daisuke Saigusa, Md Elias Al-Mamun, Mohammad A H Siddique, Junichi Omura, Taijyu Satoh, Shinichiro Sunamura, Masamichi Nogi, Kazuhiko Numano, Satoshi Miyata, Akira Uruno, Kuniyuki Kano, Yotaro Matsumoto, Takayuki Doi, Junken Aoki, Yoshiteru Oshima, Masayuki Yamamoto, Hiroaki Shimokawa
• Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA(6)Reiya Taniguchi, Asuka Inoue, Misa Sayama, Akiharu Uwamizu, Keitaro Yamashita, Kunio Hirata, Masahito Yoshida, Yoshiki Tanaka, Hideaki E. Kato, Yoshiko Nakada-Nakura, Yuko Otani, Tomohiro Nishizawa, Takayuki Doi, Tomohiko Ohwada, Ryuichiro Ishitani, Junken Aoki, Osamu Nureki
• A BRET-based assay reveals collagen-Hsp47 interaction dynamics in the endoplasmic reticulum and small-molecule inhibition of this interaction.Ito S, Saito M, Yoshida M, Takeuchi K, Doi T, Nagata K
• Total Synthesis and Conformational Analysis of Apratoxin CYuichi Masuda, Jun Suzuki, Yuichi Onda, Yuta Fujino, Masahito Yoshida, Takayuki Doi

• 致死性疾患肺高血圧症の全く新しい病因蛋白に着目した治療薬開発
• 有用天然化合物の安定的な生産技術開発新家一男
• 骨粗鬆症治療薬候補化合物デストラキシンEを量産する基盤技術の確立
• 化合物等の高機能化技術開発

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