Tohoku University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 准教授

Research keywordslipid nanoparticles・mRNA delivery・RNA vaccines・gene delivery・ionizable lipids・liver targeted nucleic acids

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• Self‐Degradable Lipid‐Like Materials Based on “Hydrolysis accelerated by the intra‐Particle Enrichment of Reactant (HyPER)” for Messenger RNA DeliveryHiroki Tanaka, Tatsunari Takahashi, Manami Konishi, Nae Takata, Masaki Gomi, Daiki Shirane, Ryo Miyama, Shinya Hagiwara, Yuki Yamasaki, Yu Sakurai, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe, Eiji Shinsho, Ruka Nishida, Kaori Fukuzawa, Etsuo Yonemochi, Koji Okuwaki, Yuji Mochizuki, Yuta Nakai, Kota Tange, Hiroki Yoshioka, Shinya Tamagawa, Hidetaka Akita
• Proteomics Analysis of Lymphatic Metastasis-Related Proteins Using Highly Metastatic Human Melanoma Cells Originated by Sequential in Vivo Implantation.Katsuyuki Chida, Yu Sakurai, Asa Ohtani, Takeshi Masuda, Sumio Ohtsuki, Hiroki Tanaka, Hidetaka Akita
• Logistics and distribution of small extracellular vesicles from the subcutaneous space to the lymphatic systemYu Sakurai, Asa Ohtani, Yuka Nakayama, Masaki Gomi, Takeshi Masuda, Sumio Ohtsuki, Hiroki Tanaka, Hidetaka Akita
• Effect of Anti-PEG Antibody on Immune Response of mRNA-Loaded Lipid Nanoparticles.Daiki Omata, Eigo Kawahara, Lisa Munakata, Hiroki Tanaka, Hidetaka Akita, Yasuo Yoshioka, Ryo Suzuki

• 外因性有機微粒子により誘起される統合的ストレス応答および二次的に放出される内因性微粒子の解析2020 · 2020年4月 ～ 2021年3月
• 脂質膜搭載素子の機能発動・解離を時空間的に制御する多重膜遺伝子ナノキャリアの創製田中 浩揮
• mRNA導入技術を基盤とする免疫抑制性樹状細胞の創出と自己免疫疾患治療田中 浩揮
• 鼻－脳輸送機構に基づく核酸送達ナノDDSの開発とグリア標的治療への応用展開金沢 貴憲, 田中 浩揮, 小菅 康弘

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