Tohoku University · Faculty of Medicine / Graduate School of Medical Sciences · 講師

Research keywordsNRF2 signaling・Keap1-NRF2 pathway・hematopoietic stem cells・oxidative stress response・sulfur metabolism・mitochondrial regulation・autoimmune inflammation・ferroptosis・NRF2-addicted cancers

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• NRF2 signalling in cytoprotection and metabolism.Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi
• IL-11 contribution to tumorigenesis in an NRF2 addiction cancer modelH. Kitamura, Y. Onodera, S. Murakami, T. Suzuki, H. Motohashi
• Nucleomethylin deficiency impairs embryonic erythropoiesis.Shohei Murakami, Takuma Suzuki, Wataru Yokoyama, Satoko Yagi, Keita Matsumura, Yuka Nakajima, Hideo Harigae, Akiyoshi Fukamizu, Hozumi Motohashi
• NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea.Yohei Honkura, Hirotaka Matsuo, Shohei Murakami, Masayuki Sakiyama, Kunio Mizutari, Akihiro Shiotani, Masayuki Yamamoto, Ichiro Morita, Nariyoshi Shinomiya, Tetsuaki Kawase, Yukio Katori, Hozumi Motohashi

• Nrf2誘導剤による造血幹細胞の活性化とその分子機構の解明村上 昌平, 鈴木 琢磨
• 巨核球・赤血球前駆細胞におけるミトコンドリア依存的な分化制御機構の解明村上 昌平
• 造血幹細胞におけるポリスルフィド依存的なミトコンドリア機能の解明村上 昌平
• アレルギー疾患における肥満細胞と好塩基球の分化・産生に関わる分子機構の解明と、Keap1-Nrf2制御系を標的とした治療法開発の有効性の検討村上昌平

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