Tohoku University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 准教授

Research keywordsmethylmercury toxicity・electrophilic metals・protein thiols・ornithine decarboxylase・putrescine・Nrf2 pathway・selenium transport・selenoprotein P・hepatocyte toxicology

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• Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytesYasuhiro Shinkai, Daigo Sumi, Takashi Toyama, Toshiyuki Kaji, Yoshito Kumagai
• Induction of chemokine CCL3 by NF-κB reduces methylmercury toxicity in C17.2 mouse neural stem cells.Takahashi T, Kim MS, Iwai-Shimada M, Hoshi T, Fujimura M, Toyama T, Fujiwara Y, Naganuma A, Hwang GW
• Arsenite sensitizes to ferroptosis by disrupting selenium metabolism and reducing GPx4 expressionHayato Takashima, Reiko Makino, Hiroki Taguchi, Junya Ito, Eikan Mishima, Yoshika Takenaka, Yasutoshi Akiyama, Daigo Sumi, Marcus Conrad, Yoshihisa Tomikoka, Takashi Toyama, Yoshiro Saito
• Cysteine redoxome landscape in the liver of male mice fed a high-fat high-sucrose dietCynthia M. Galicia-Medina, Hein Ko Oo, Takumi Nishiuchi, Ryota Tanida, Tuerdiguli Abuduyimiti, Hisanori Goto, Yujiro Nakano, Yumie Takeshita, Kiyo-aki Ishii, Takashi Toyama, Yoshiro Saito, Hiroaki Takayama, Toshinari Takamura

• 含セレン化合物のミックスモード作用を介したウイルス増殖抑制剤の開発外山喬士, 松永哲郎, 有澤美枝子
• 生命金属と有害金属のメタル相互作用を介した生体機能撹乱外山 喬士
• メチル水銀によるミクログリア活性化を介した中枢神経傷害作用外山 喬士
• 分泌タンパク質による産生細胞の直接的な代謝制御機構の解明に向けた挑戦的研究斎藤 芳郎, 外山 喬士, 有澤 琴子

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