Tohoku University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 准教授

Research keywordsbiology・Cell・Gタンパク質共役型受容体(GPCR)・protein-coupled・receptor

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• Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRsEva Marie Pfeil, Julian Brands, Nicole Merten, Timo Vögtle, Maddalena Vescovo, Ulrike Rick, Ina Maria Albrecht, Nina Heycke, Kouki Kawakami, Yuki Ono, Francois Marie Ngako Kadji, Suzune Hiratsuka, Junken Aoki, Felix Häberlein, Michaela Matthey, Jaspal Garg, Stephanie Hennen, Marie Lise Jobin, Kerstin Seier, Davide Calebiro, Alexander Pfeifer, Akos Heinemann, Daniela Wenzel, Gabriele M. König, Bernhard Nieswandt, Bernd K. Fleischmann, Asuka Inoue, Katharina Simon, Evi Kostenis
• Phosphorylation barcodes direct biased chemokine signaling at CXCR3.Dylan S Eiger, Jeffrey S Smith, Tujin Shi, Tomasz Maciej Stepniewski, Chia-Feng Tsai, Christopher Honeycutt, Noelia Boldizsar, Julia Gardner, Carrie D Nicora, Ahmed M Moghieb, Kouki Kawakami, Issac Choi, Chloe Hicks, Kevin Zheng, Anmol Warman, Priya Alagesan, Nicole M Knape, Ouwen Huang, Justin D Silverman, Richard D Smith, Asuka Inoue, Jana Selent, Jon M Jacobs, Sudarshan Rajagopal
• Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs.Yuki Ono, Kouki Kawakami, Gaku Nakamura, Satoru Ishida, Junken Aoki, Asuka Inoue
• The dynamic basis of G-protein recognition and activation by a GPCR.Kazuhiro Kobayashi, Kouki Kawakami, Toshiki E Matsui, Shun Yokoi, Masahiro Fukuda, Tomohiro J Narita, Hiroki Arai, Mai Tambo, Takashi Sumikama, Manae Tatsumi, Keitaro Yamashita, Junki Koyanagi, Mai Kugawa, Hisako Ikeda, Ayumi Sumino, Ayori Mitsutake, Brian K Kobilka, Asuka Inoue, Hideaki E Kato

• 易活性化型変異を導入した人工Ｇタンパク質共役型受容体の創製と応用川上 耕季
• GPCR網羅的な内在化経路の同定と内在化経路選択の構造基盤解明川上 耕季
• コア型βアレスチンの機能とその分子基盤の解明川上 耕季
• GPCR低分子創薬を加速する革新的DELスクリーニングプラットフォーム開発研究加藤 英明, 川上 耕季

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