Tohoku University · Institute of Development, Aging and Cancer · 助教

Research keywordsmitochondrial diseases・mitochondrial RNA processing・mtDNA mutations・mitochondrial translation・Mitofusin 2・Shmt2・mitochondrial respiration・mitochondrial proteostasis

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• Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation.Haruna Tani, Kaori Ishikawa, Hiroaki Tamashiro, Emi Ogasawara, Takehiro Yasukawa, Shigeru Matsuda, Akinori Shimizu, Dongchon Kang, Jun-Ichi Hayashi, Fan-Yan Wei, Kazuto Nakada
• Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior.Kaori Ishikawa, Satoshi Yamamoto, Satoko Hattori, Naoya Nishimura, Haruna Tani, Takayuki Mito, Hirokazu Matsumoto, Tsuyoshi Miyakawa, Kazuto Nakada
• Monitoring the complexity and dynamics of mitochondrial translation.Taisei Wakigawa, Mari Mito, Yushin Ando, Haruna Yamashiro, Kotaro Tomuro, Haruna Tani, Kazuhito Tomizawa, Takeshi Chujo, Asuteka Nagao, Takeo Suzuki, Osamu Nureki, Fan-Yan Wei, Yuichi Shichino, Yuzuru Itoh, Tsutomu Suzuki, Shintaro Iwasaki
• Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice.Akinori Shimizu, Haruna Tani, Gaku Takibuchi, Kaori Ishikawa, Ryota Sakurazawa, Takafumi Inoue, Tetsuo Hashimoto, Kazuto Nakada, Keizo Takenaga, Jun-Ichi Hayashi

• ミトコンドリアゲノム編集技術が拓く疾患治療の新展開谷 春菜
• ミトコンドリア疾患モデルの樹立による病態形成機構の解明谷 春菜
• ｍｔＤＮＡに病原性突然変異を有する新規ミトコンドリア病モデルマウスの作出と解析谷 春菜
• 新規mtDNA塩基編集ツールを用いたミトコンドリア病モデルマウスの樹立谷 春菜

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