Tohoku University · Faculty of Agriculture / Graduate School of Agriculture · 准教授

Research keywordsgamma-secretase・amyloid beta・presenilin・BACE1 trafficking・yeast reconstitution・polyalanine toxicity・protein glycosylation・Alzheimer disease

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• ADAM19 autolysis is activated by LPS and promotes non-classical secretion of cysteine-rich protein 2Chiaki Tanabe, Nika Hotoda, Noboru Sasagawa, Eugene Futai, Hiroto Komano, Shoichi Ishiura
• Advanced Yeast Models of Familial Alzheimer Disease Expressing FAD-Linked Presenilin to Screen Mutations and γ-Secretase Modulators.Eugene Futai
• Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation.Yasuomi Urano, Mina Takahachi, Ryo Higashiura, Hitomi Fujiwara, Satoru Funamoto, So Imai, Eugene Futai, Michiaki Okuda, Hachiro Sugimoto, Noriko Noguchi
• Inhibition by KMI-574 Leads to Dislocalization of BACE1 From Lipid RaftsMaiko Ebina, Eugene Futai, Chiaki Tanabe, Noboru Sasagawa, Yoshiaki Kiso, Shoichi Ishiura

• 新しいアッセイ法による認知症治療薬の効果判定制度名： Grant-in-Aid for Scientific Research
• 出芽酵母カルパイン、CplIpのストレス応答経路における機能の解析二井 勇人
• 認知症における微小管重合調節異常と薬剤探索内田 隆史, 内田 千代子, 山下 まり, 広瀬 恵子, 奥田 徹, 二井 勇人
• 認知症治療薬の開発を目指した膜内切断プロテアーゼ調節機構の解析二井 勇人, 新谷 尚弘

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