Tohoku University · Graduate School of Life Sciences · 助教

Research keywordsPROTAC・ミトコンドリア・標的タンパク質分解・神経変性疾患

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• Well-to-well transfer of HaloTag ligand 6-chlorohexan-1-ol and formaldehyde in a multi-well plateYugo Mishima, Saori Yasuda, Aoi Kunitomi, Tokiha Masuda-Ozawa, Shusuke Tomoshige, Shunji Kato, Yuki Kadono, Kiyotaka Nakagawa, Minoru Ishikawa
• Synthetic and Biological Studies of Juglorubin and Related NaphthoquinonesShogo Kamo, Tatsuo Saito, Yasuha Kusakabe, Shusuke Tomoshige, Masanobu Uchiyama, Kazunori Tsubaki, Kouji Kuramochi
• Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like PropertiesKeigo Hirai, Hiroko Yamashita, Shusuke Tomoshige, Yugo Mishima, Tatsuya Niwa, Kenji Ohgane, Mayumi Ishii, Kayoko Kanamitsu, Yui Ikemi, Shinsaku Nakagawa, Hideki Taguchi, Shinichi Sato, Yuichi Hashimoto, Minoru Ishikawa
• Synthesis of nucleotide analogues, EFdA, EdA and EdAP, and the effect of EdAP on hepatitis B virus replication.Mai Kamata, Toshifumi Takeuchi, Ei Hayashi, Kazane Nishioka, Mizuki Oshima, Masashi Iwamoto, Kota Nishiuchi, Shogo Kamo, Shusuke Tomoshige, Koichi Watashi, Shinji Kamisuki, Hiroshi Ohrui, Fumio Sugawara, Kouji Kuramochi

• ミトコンドリア操作を見据えたタンパク質分解法の開発2024 · 2024年1月 ～ 2025年4月
• 細胞周期制御タンパク質を利用する化学的タンパク質分解手法の開発2020 · 2020年3月 ～ 2021年2月
• 低分子化合物による標的ﾀﾝﾊﾟｸ質分解誘導手法の拡張―膜ﾀﾝﾊﾟｸ質分解誘導への展開と新規がん治療戦略の提案―友重 秀介
• 薬剤耐性菌に有効な多機能型抗生物質の創製友重 秀介

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