Tohoku University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 教授

Research keywords薬物治療学・薬物動態学・薬物代謝学・臨床薬剤学・ゲノム薬理学・Genetics・Gene・Allele

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• Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation ActivitiesHiroki Hosono, Masaki Kumondai, Masamitsu Maekawa, Hiroaki Yamaguchi, Nariyasu Mano, Akifumi Oda, Noriyasu Hirasawa, Masahiro Hiratsuka
• Competitive allele-specific short oligonucleotide hybridization (CASSOH) with enzyme-linked immunosorbent assay (ELISA) for the detection of pharmacogenetic single nucleotide polymorphisms (SNPs)M Hiratsuka, A Ebisawa, K Sakuyama, Y Matsubara, S Kure, Y Soya, Y Konno, T Sasaki, A Kishiba, M Mizugaki
• PREDICTION OF THREE-DIMENSIONAL STRUCTURES AND STRUCTURAL FLEXIBILITIES OF WILD-TYPE AND MUTANT CYTOCHROME P450 1A2 BY MOLECULAR DYNAMICS SIMULATIONSWatanabe Yurie, Fukuyoshi Shuichi, Hiratsuka Masahiro, Yamaotsu Noriyuki, Oda Akifumi
• Molecular analysis of new Japanese patients with holocarboxylase synthetase deficiencyO Sakamoto, Y Suzuki, Y Aoki, Li, X, M Hiratsuka, K Yanagihara, K Inui, T Okabe, S Yamaguchi, J Kudoh, N Shimizu, K Narisawa

• 発がん前駆物質を代謝活性化するシトクロムP450の遺伝的バリアント機能変化の解明
• フッ化ピリミジン系抗がん剤の副作用予測を目指した代謝酵素レアバリアントの網羅的機能解析
• 健常人バイオバンクを活用した薬物代謝酵素遺伝子多型バリアントの網羅的機能変化解析による薬物応答性予測パネルの構築
• イムノチップを用いた薬剤反応性遺伝子のベッドサイドSNP検出法の開発

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