Tohoku University · Faculty of Medicine / Graduate School of Medical Sciences · 講師

Research keywordssupersulfides・reactive sulfur species・nitric oxide signaling・S-glutathionylation・protein kinase redox regulation・aminoacyl-tRNA synthetases・electrophile detoxification

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• Reactive sulfur species inactivate Ca 2+ /calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residueTsuyoshi Takata, Hideshi Ihara, Naoya Hatano, Yukihiro Tsuchiya, Takaaki Akaike, Yasuo Watanabe
• Synthesis of Sulfides and Persulfides Is Not Impeded by Disruption of Three Canonical Enzymes in Sulfur Metabolism.Qamarul Hafiz Zainol Abidin, Tomoaki Ida, Masanobu Morita, Tetsuro Matsunaga, Akira Nishimura, Minkyung Jung, Naim Hassan, Tsuyoshi Takata, Isao Ishii, Warren Kruger, Rui Wang, Hozumi Motohashi, Masato Tsutsui, Takaaki Akaike
• Redox regulation of Ca 2+ /calmodulin-dependent protein kinase IV via oxidation of its active-site cysteine residueTsuyoshi Takata, Jun Kimura, Hideshi Ihara, Naoya Hatano, Yukihiro Tsuchiya, Yasuo Watanabe
• Control of protein function through oxidation and reduction of persulfidated statesÉ. Dóka, T. Ida, M. Dagnell, Y. Abiko, N. C. Luong, N. Balog, T. Takata, B. Espinosa, A. Nishimura, Q. Cheng, Y. Funato, H. Miki, J. M. Fukuto, J. R. Prigge, E. E. Schmidt, E. S.J. Arnér, Y. Kumagai, T. Akaike, P. Nagy

• 病原細菌における新規活性イオウ分子産生系の発見と病原性発現機構の解明藤井 重元, 井田 智章, 高田 剛
• カルモデュリンキナーゼの活性イオウ応答性とその意義（課題番号 H27-3）高田 剛
• 超硫黄分子によるエネルギー代謝と酸化ストレスシグナル機能の解明赤池 孝章, 松永 哲郎, 三木 裕明, 高田 剛, 村上 一馬
• パースルフィドによるタンパク質酸化損傷修復メカニズムの解明高田 剛

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