Tohoku University · Faculty of Medicine / Graduate School of Medical Sciences · 准教授

Research keywordsBACH2・C-EBP regulatory network・hematopoietic progenitors・plasma cell differentiation・IRF4・pre-BCR signaling・IL-7 signaling・transcription factor networks

Research fields医化学・転写因子機能制御

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• Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors.Daisuke Kurotaki, Jun Nakabayashi, Akira Nishiyama, Haruka Sasaki, Wataru Kawase, Naofumi Kaneko, Kyoko Ochiai, Kazuhiko Igarashi, Keiko Ozato, Yutaka Suzuki, Tomohiko Tamura
• A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiationKyoko Ochiai, Mark Maienschein-Cline, Malay Mandal, Joseph R. Triggs, Eric Bertolino, Roger Sciammas, Aaron R. Dinner, Marcus R. Clark, Harinder Singh
• S-Adenosylmethionine Synthesis Is Regulated by Selective N-6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1Hiroki Shima, Mitsuyo Matsumoto, Yuma Ishigami, Masayuki Ebina, Akihiko Muto, Yuho Sato, Sayaka Kumagai, Kyoko Ochiai, Tsutomu Suzuki, Kazuhiko Igarashi
• Protocol for in vitro BCR-mediated plasma cell differentiation and purification of chromatin-associated proteins.Kyoko Ochiai, Hiroki Shima, Tsuyoshi Ikura, Marissa C Franke, Evelyn P Sievert, Roger Sciammas, Kazuhiko Igarashi

• 多発性骨髄腫で転写因子IKAROSの不安定化を促進する新規化合物の開発落合 恭子
• がん細胞のBACH1依存性を活用した新規治療戦略の開発五十嵐 和彦, 島 弘季, 落合 恭子, 西澤 弘成, 松本 光代
• エピゲノム制御によるDNA損傷修復機構と細胞分化落合 恭子
• 転写因子IRF4タンパク質分解制御から解明するメモリーB細胞分化誘導機構落合 恭子

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