Tohoku University · Graduate School of Life Sciences · 教授

Research keywordsopioid receptors・delta opioid receptor agonists・liver X receptor modulators・aqueous solubility optimization・protein degradation・medicinal chemistry・antiviral analogs

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• meta-Non-flat substituents: a novel molecular design to improve aqueous solubility in small molecule drug discoveryYuki Ichikawa, Michiaki Hiramatsu, Yusuke Mita, Makoto Makishima, Yotaro Matsumoto, Yui Masumoto, Atsuya Muranaka, Masanobu Uchiyama, Yuichi Hashimoto, Minoru Ishikawa
• Challenges of Aufheben to Promote Druglikeness: Chemical Modification Strategies to Improve Aqueous Solubility and PermeabilityMinoru Ishikawa, Shusuke Tomoshige, Shinichi Sato
• Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligandsShioi R, Toyota Y, Noguchi-Yachide T, Ishikawa M, Yamaguchi T, Makishima M, Hashimoto Y, Ohgane K
• Synthesis of potent αvβ3/α IIbβ3 dual antagonists tricyclic pharmacophore-based molecules and their selectivity controlIshikawa M, Kubota D, Ajito K

• ケミカルプロテインノックダウン技術の開発と細胞制御内藤 幹彦, 伊藤 拓水, 石川 稔, 出水 庸介
• 多次元同時阻害作用を有する核内受容体機能阻害薬の創製研究石川 稔
• ケモテクノロジーが拓くユビキチンニューフロンティア内藤 幹彦
• 化合物が導くリバース翻訳後修飾プロテオミクス石川 稔

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