Tokai University · Graduate School of Medicine / Faculty of Medicine · 准教授

Research keywordsinflammatory bowel disease・ulcerative colitis・intestinal Behcet disease・intestinal macrophages・IL-12・IL-23・mucosal healing・Helicobacter pylori

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• Association between the interleukin-1 receptor antagonist polymorphism and ulcerative colitis with younger age at diagnosis
• A specific genetic alteration on chromosome 6 in ulcerative colitis-associated colorectal cancers
• CD4(+) INTESTINAL MUCOSAL LYMPHOCYTES IN THE PATHOGENESIS OF CROHNS-DISEASE
• T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease

• クローン病類似大腸炎モデルの作製と_CD4による新たな治療法の開発
• 患者由来末梢血幹細胞の移入による新しいCrohn病モデルマウスの開発
• 潰瘍性大腸炎合併大腸癌に対する新しいサーベイランス法の確立-抗p53抗体の有用性
• クローン病の病態における細胞内寄生細菌に対するオートファジー機能異常の重要性

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