Tokai University · Graduate School of Medicine / Faculty of Medicine

Research keywordsALS・運動ニューロン疾患・神経変性疾患・初期エンドソーム・低分子量Gタンパク質・ゴルジ体・グアニンヌクレオチド交換因子・アンフィソーム・Rab・iPS細胞

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• The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2.
• Molecular and cellular function of ALS2/alsin: Implication of membrane dynamics in neuronal development and degeneration
• A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice.
• Disturbance of endolysosomal protein degradation underlies the pathogenesis of ALS2-linked motor neuron diseases

• 生理的機能を有するALS細胞モデルの構築とその病態解析
• Ｗ染色体とＹ染色体に制御される性差構築
• 家族性筋萎縮性側索硬化症2型疾患iPS細胞の樹立とALS2疾患モデル細胞の作出
• 運動ニューロンの恒常性維持に関わる分子機構の解明

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