Tokai University · Graduate School of Medicine / Faculty of Medicine

Research keywordsDNA複製・22q11.2欠失症候群・DGCR8・DNA損傷応答・Rループ・ヌクレオチド除去修復・癌遺伝子・紫外線

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• Homology-mediated end-capping as a primary step of sister chromatid fusion in the breakage-fusion-bridge cycles
• Complex repeat structure promotes hyper-amplification and amplicon evolution through rolling-circle replication.
• Double rolling circle replication (DRCR) is recombinogenic
• DGCR8 regulates multiple processes of transcription coupled nucleotide excision repair

• Regulation of the Fanconi anemia-BRCA pathway
• microRNA生合成因子のDNA修復における新規機能の解明
• microRNA生合成因子のDNA修復における新規機能の解明
• 多機能RNA結合因子DGCR8による紫外線誘導性RNA関連障害応答の制御ネットワークの解明

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