Tokai University · Graduate School of Medicine / Faculty of Medicine · 教授

Research keywordshematopoietic stem cells・mesenchymal stem cells・NOD SCID mice・oxidative DNA damage・NKT cell activation・antitumor effector cells

Research fieldsImmunology・Tumor biology・血液、腫瘍内科学

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• Reconstitution of immune systems in RAG2-/- mice by transfer with interleukin-12-induced splenic hematopoietic progenitor cells.
• Inhibition of plasminogen activator inhibitor type-1 activity enhances rapid and sustainable hematopoietic regeneration.
• Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis
• IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform.

• エフェロサイトーシス促進薬による慢性炎症性疾患治療法の開発
• Notchシグナル活性化による骨代謝制御と骨肉腫発症の分子メカニズムの解明
• ヒト造血システムモデルマウスの作成とヒト造血幹細胞の制御機構の解明
• 骨髄異形成症候群の発症メカニズムに与える活性酸素（ROS)の影響

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