Tokai University · Graduate School of Medicine / Faculty of Medicine · 助教

Research keywordsalopecia areata・MHC haplotypes・hair keratinization・artificial miRNA・piggyBac transposition・gene transfer・stable transfectants・mouse genetics

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• Thy1 promoter activity in the Rosa26 locus in mice: lessons from Dre-rox conditional expression system.
• Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT
• Three-dimensional X-ray visualization of axonal tracts in mouse brain hemisphere.
• Establishment of immortalized mesenchymal stem cells derived from the submandibular glands of tdTomato transgenic mice.

• in vivoゲノム編集効率の最適化と疾患モデル動物遺伝子治療への応用
• イントロンの改変による遺伝子発現制御系の確立と糖尿病関連遺伝子機能解析への応用
• 採卵・顕微注入・移植を要しない、新しい遺伝子改変マウス作製法の開発と応用
• CRISPRとインテグラーゼを併用した長鎖DNA挿入法の確立とマウス作製への応用

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